Repeated USMLE Questions Step 1- Highlights- 3

Q- Which of the following drugs reduces blood pressure by centrally acting on vasomotor centers?

A- Atenolol

B- Clonidine

C- Enalapril

D- Nifedipine

B- Clonidine- It is not indicated for initial therapy of hypertension but it may be used later in combination with other drugs. Its use leads to central alpha 2-adrenergic stimulation which results in decreased sympathetic outflow to the heart, kidney and peripheral vessels.

Q- Which of the following drugs may cause reversible gynecomastia?

A- Cimetidine

B- Omeprazole

C- Misoprostol

D- Sucralfate

A- Cimetidine- It may causes headache and gynecomastia in 2-4% of patients. It also can cause dizziness and somnolence.

Q- Which of the following is the most accurate definition of tachyphylaxis?

A- A decrease of the effect of drugs after use for a prolonged time

B- A drug interaction between two drugs

C- A toxic effect after repeated use of the same drugs in a short period of time

D- Very rapidly developing tolerance for a drug

C- Very rapidly developing tolerance for a drug- It is a rapid diminishing response to drugs after successive doses. It is common in neurologic and psychiatric drugs.  

More Repeated USMLE Questions Step 1

Check this Review Book for Step 1

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