A 9 month-old boy presents to the emergency room with a high fever and persistent cough.  Workup confirms a diagnosis of pneumococcal pneumonia. His past history shows multiple episodes of otitis media. His weight and height are at the 5th percentile.

What is the most likely diagnosis?

A-Chediak-Higashi Syndrome

B-Chronic granulomatous disease

C-Leukocyte adhesion defect

D-X-linked agammaglobulinemia

E-Wiskott-Aldrich Syndrome


This boy most likely has x-linked agammaglobulinemia. This disorder is characterized by decrease in B-cell production which leads to less production of antibodies Which leads to recurrent bacterial infections as seen in this patient.

The correct answer is D