A 1-year-old boy is brought to the physician by his parents due to repeated upper respiratory tract infections and oral fungal infections. Physical examination reveals low set ears and fish-like mouth. Laboratory tests reveal hypocalcemia and chest x-ray shows no thymus shadow.
What is the most likely cause of hypocalcemia in this case?
A- Decreased secretion of parathyroid hormone
B- End-organ hyposensitivity to parathyroid hormone
C- End-organ hyposensitivity to calcitonin
D- Increased secretion of calcitonin
E- Increased secretion of parathyroid hormone
This case is most likely Di George syndrome. It is characterized by a defect in the third pharyngeal pouch which gives rise to inferior parathyroids and thymus. The fourth pharyngeal pouch gives rise to superior parathyroids.
The correct answer is A