A 34-year-old man newly immigrant from Kenya presents to your office for fever, sore throat and general aches. He has a long history of malaria and takes daily primaquine. Throat swab reveals streptococcal infection. You decide to prescribe an antibiotic.
Which of these antibiotics is contraindicated for this patient?
Erythromycin blocks the metabolism of primaquine by the liver through depressing the P450 system. This leads to accumulation of primaquine causing toxicity.
The correct answer is D